Overview
SCIENTIFIC SCORE
Possibly Effective
Based on 21 Researches
7.5
USERS' SCORE
Moderately Good
Based on 4 Reviews
7.9
Supplement Facts
Serving Size: 1 Veggie Capsule
Amount Per Serving
%DV
Selenium (from SelenoExcell® High Selenium Yeast) (Saccharomyces cerevisiae)
50 mcg
90%
Molybdenum (from molybdenum glycinate chelate)
50 mcg
110%
N-Acetylcysteine (NAC)
600 mg
†
Top Medical Research Studies
9
We investigated how selenium supplementation affects cholesterol levels and the associated molecular changes. Using Sprague-Dawley male rats, we fed them diets supplemented with selenium alongside high cholesterol for three months.
The results showed that while apolipoprotein B levels rose with the cholesterol diet, supplementing with 1 ppm of selenium significantly reduced these levels. Additionally, the expression of HMG-CoA reductase also decreased with selenium supplementation.
Overall, our findings suggest that selenium could offer a supportive role in managing lipid metabolism and high cholesterol.
The results showed that while apolipoprotein B levels rose with the cholesterol diet, supplementing with 1 ppm of selenium significantly reduced these levels. Additionally, the expression of HMG-CoA reductase also decreased with selenium supplementation.
Overall, our findings suggest that selenium could offer a supportive role in managing lipid metabolism and high cholesterol.
9
Selenium nanoparticles show limited effectiveness
We investigated whether selenium nanoparticles (SeNPs) could combat atherosclerosis related to high cholesterol. In our study involving apolipoprotein E deficient mice on a high-fat diet, both BSA- and chitosan-coated SeNPs showed promise in reducing atherosclerotic lesions over 12 weeks.
The nanoparticles seemed to work by lowering cholesterol levels and boosting antioxidant activity. While results were notably stronger for BSA-SeNPs, there was no significant evidence to suggest that SeNPs drastically alter cholesterol levels overall, indicating that further research is necessary.
The nanoparticles seemed to work by lowering cholesterol levels and boosting antioxidant activity. While results were notably stronger for BSA-SeNPs, there was no significant evidence to suggest that SeNPs drastically alter cholesterol levels overall, indicating that further research is necessary.
9
We explored the effects of selenium nanoparticles on high cholesterol by studying ApoE-deficient mice on a high-fat diet. Over eight weeks, we noted that selenium nanoparticles significantly reduced total cholesterol and triglycerides while boosting beneficial HDL levels.
Additionally, these nanoparticles improved vascular health and regulated important genes for cholesterol metabolism while enhancing antioxidant enzyme activities. However, it's important to note that while the results were promising in mice, the findings do not directly translate to humans yet.
Additionally, these nanoparticles improved vascular health and regulated important genes for cholesterol metabolism while enhancing antioxidant enzyme activities. However, it's important to note that while the results were promising in mice, the findings do not directly translate to humans yet.
Most Useful Reviews
9
Normalised transaminase levels
1 people found this helpful
I have slightly elevated transaminase levels and take this product daily while on a statin every other day. After about two months, a review showed my transaminase levels returned to normal.
6
Recommended antioxidant
50 people found this helpful
NAC is an exceptional antioxidant and my go-to remedy. I use it for sports and during illnesses to enhance my immune system and reduce cholesterol. It is indeed an invaluable addition to my health regimen!
7.5
Detoxification support
2 people found this helpful
This product offers perfect detoxification and supports the immune system against numerous issues, including high cholesterol and allergies. I am a satisfied purchaser.
Medical Researches
SCIENTIFIC SCORE
Possibly Effective
Based on 21 Researches
7.5
- All Researches
9
Selenium nanoparticles show limited effectiveness
We investigated whether selenium nanoparticles (SeNPs) could combat atherosclerosis related to high cholesterol. In our study involving apolipoprotein E deficient mice on a high-fat diet, both BSA- and chitosan-coated SeNPs showed promise in reducing atherosclerotic lesions over 12 weeks.
The nanoparticles seemed to work by lowering cholesterol levels and boosting antioxidant activity. While results were notably stronger for BSA-SeNPs, there was no significant evidence to suggest that SeNPs drastically alter cholesterol levels overall, indicating that further research is necessary.
The nanoparticles seemed to work by lowering cholesterol levels and boosting antioxidant activity. While results were notably stronger for BSA-SeNPs, there was no significant evidence to suggest that SeNPs drastically alter cholesterol levels overall, indicating that further research is necessary.
9
We explored the effects of selenium nanoparticles on high cholesterol by studying ApoE-deficient mice on a high-fat diet. Over eight weeks, we noted that selenium nanoparticles significantly reduced total cholesterol and triglycerides while boosting beneficial HDL levels.
Additionally, these nanoparticles improved vascular health and regulated important genes for cholesterol metabolism while enhancing antioxidant enzyme activities. However, it's important to note that while the results were promising in mice, the findings do not directly translate to humans yet.
Additionally, these nanoparticles improved vascular health and regulated important genes for cholesterol metabolism while enhancing antioxidant enzyme activities. However, it's important to note that while the results were promising in mice, the findings do not directly translate to humans yet.
9
Selenium may help cholesterol levels
We investigated the effects of selenium supplementation on LDL receptor activity and mRNA expression in male rats with high cholesterol. The study involved feeding the rats diets with varying selenium levels along with a high-cholesterol diet over three months.
Our results showed that while high cholesterol reduced both LDL receptor activity and mRNA expression, selenium at 1 ppm effectively improved these measures. This suggests that selenium may play a positive role in managing cholesterol levels and supporting lipid metabolism.
Our results showed that while high cholesterol reduced both LDL receptor activity and mRNA expression, selenium at 1 ppm effectively improved these measures. This suggests that selenium may play a positive role in managing cholesterol levels and supporting lipid metabolism.
9
We investigated how selenium supplementation affects cholesterol levels and the associated molecular changes. Using Sprague-Dawley male rats, we fed them diets supplemented with selenium alongside high cholesterol for three months.
The results showed that while apolipoprotein B levels rose with the cholesterol diet, supplementing with 1 ppm of selenium significantly reduced these levels. Additionally, the expression of HMG-CoA reductase also decreased with selenium supplementation.
Overall, our findings suggest that selenium could offer a supportive role in managing lipid metabolism and high cholesterol.
The results showed that while apolipoprotein B levels rose with the cholesterol diet, supplementing with 1 ppm of selenium significantly reduced these levels. Additionally, the expression of HMG-CoA reductase also decreased with selenium supplementation.
Overall, our findings suggest that selenium could offer a supportive role in managing lipid metabolism and high cholesterol.
9
We explored how selenium affects lipid levels in rats consuming a high-cholesterol diet over ten weeks. By comparing selenium-treated groups with control rats, we found that selenium effectively reduced triglycerides, total cholesterol, and low-density lipoprotein cholesterol.
Additionally, it inhibited liver fat accumulation. These findings suggest that selenium could play a beneficial, recuperative role against high cholesterol. However, it's important to note that this research is based on animal studies, so human applicability requires further investigation.
Additionally, it inhibited liver fat accumulation. These findings suggest that selenium could play a beneficial, recuperative role against high cholesterol. However, it's important to note that this research is based on animal studies, so human applicability requires further investigation.
User Reviews
USERS' SCORE
Moderately Good
Based on 4 Reviews
7.9
- All Reviews
- Positive Reviews
- Negative Reviews
9
Normalised transaminase levels
1 people found this helpful
I have slightly elevated transaminase levels and take this product daily while on a statin every other day. After about two months, a review showed my transaminase levels returned to normal.
6
Recommended antioxidant
50 people found this helpful
NAC is an exceptional antioxidant and my go-to remedy. I use it for sports and during illnesses to enhance my immune system and reduce cholesterol. It is indeed an invaluable addition to my health regimen!
7.5
Detoxification support
2 people found this helpful
This product offers perfect detoxification and supports the immune system against numerous issues, including high cholesterol and allergies. I am a satisfied purchaser.
6
Immune system boost
2 people found this helpful
It aids detoxification and supports the immune system while effectively addressing issues related to high cholesterol and allergies. A commendable product.
Frequently Asked Questions
9
Normalised transaminase levels
1 people found this helpful
I have slightly elevated transaminase levels and take this product daily while on a statin every other day. After about two months, a review showed my transaminase levels returned to normal.
7.5
Detoxification support
2 people found this helpful
This product offers perfect detoxification and supports the immune system against numerous issues, including high cholesterol and allergies. I am a satisfied purchaser.
6
Recommended antioxidant
50 people found this helpful
NAC is an exceptional antioxidant and my go-to remedy. I use it for sports and during illnesses to enhance my immune system and reduce cholesterol. It is indeed an invaluable addition to my health regimen!
6
Immune system boost
2 people found this helpful
It aids detoxification and supports the immune system while effectively addressing issues related to high cholesterol and allergies. A commendable product.
7
We examined the effects of two strains of Saccharomyces cerevisiae, along with Kluyveromyces marxianus, isolated from Algerian fruits. These promising yeast strains showed strong probiotic qualities and survived harsh conditions like low pH and bile.
The study revealed a cholesterol reduction of about 33% from both S. cerevisiae strains and an impressive 54.32% from K. marxianus. Although K. marxianus outperformed in terms of cholesterol assimilation, all strains displayed antioxidant potential, making them suitable candidates for innovative functional foods and probiotic applications.
The study revealed a cholesterol reduction of about 33% from both S. cerevisiae strains and an impressive 54.32% from K. marxianus. Although K. marxianus outperformed in terms of cholesterol assimilation, all strains displayed antioxidant potential, making them suitable candidates for innovative functional foods and probiotic applications.
8
Saccharomyces reduces cholesterol effectively
We aimed to compare the effects of nutraceuticals and antibiotic growth promoters on various health aspects of broiler chickens. Over 35 days, 320 one-day-old male chickens were grouped and fed different diets, including a probiotic mixed with Saccharomyces cerevisiae.
Our findings showed that the probiotic group notably reduced cholesterol and total lipids while enhancing beneficial bacteria in the gut. Improvements in weight gain and meat quality were also observed. Ultimately, using probiotics like Saccharomyces cerevisiae can be a promising alternative to traditional antibiotics in poultry diets.
Our findings showed that the probiotic group notably reduced cholesterol and total lipids while enhancing beneficial bacteria in the gut. Improvements in weight gain and meat quality were also observed. Ultimately, using probiotics like Saccharomyces cerevisiae can be a promising alternative to traditional antibiotics in poultry diets.
9
We explored the effects of selenium nanoparticles on high cholesterol by studying ApoE-deficient mice on a high-fat diet. Over eight weeks, we noted that selenium nanoparticles significantly reduced total cholesterol and triglycerides while boosting beneficial HDL levels.
Additionally, these nanoparticles improved vascular health and regulated important genes for cholesterol metabolism while enhancing antioxidant enzyme activities. However, it's important to note that while the results were promising in mice, the findings do not directly translate to humans yet.
Additionally, these nanoparticles improved vascular health and regulated important genes for cholesterol metabolism while enhancing antioxidant enzyme activities. However, it's important to note that while the results were promising in mice, the findings do not directly translate to humans yet.
9
We explored how selenium affects lipid levels in rats consuming a high-cholesterol diet over ten weeks. By comparing selenium-treated groups with control rats, we found that selenium effectively reduced triglycerides, total cholesterol, and low-density lipoprotein cholesterol.
Additionally, it inhibited liver fat accumulation. These findings suggest that selenium could play a beneficial, recuperative role against high cholesterol. However, it's important to note that this research is based on animal studies, so human applicability requires further investigation.
Additionally, it inhibited liver fat accumulation. These findings suggest that selenium could play a beneficial, recuperative role against high cholesterol. However, it's important to note that this research is based on animal studies, so human applicability requires further investigation.
References
- Barache N, Belguesmia Y, Zeghbib W, Ladjouzi R, Ouarabi L, et al. Characterization and Biological In Vitro Screening of Probiotic Yeast Strains Isolated from Algerian Fruits. Probiotics Antimicrob Proteins. 2024. doi:10.1007/s12602-024-10389-y
- Selim S, Abdel-Megeid NS, Alhotan RA, Ebrahim A, Hussein E. Nutraceuticals vs. antibiotic growth promoters: differential impacts on performance, meat quality, blood lipids, cecal microbiota, and organ histomorphology of broiler chicken. Poult Sci. 2024;103:103971. doi:10.1016/j.psj.2024.103971
- Hosseini H, Abbasi A, Sabahi S, Akrami S, Yousefi-Avarvand A. Assessing the Potential Biological Activities of Postbiotics Derived from Saccharomyces cerevisiae: An In Vitro Study. Probiotics Antimicrob Proteins. 2024;16:1348. doi:10.1007/s12602-023-10117-y
- Wang Y, Han C, Cheng J, Wang Z, Liu L, et al. Fermented Cerasus humilis fruits protect against high-fat diet induced hyperlipidemia which is associated with alteration of gut microbiota. J Sci Food Agric. 2023;103:2554. doi:10.1002/jsfa.12377
- Razavi SA, Pourjafar M, Hajimohammadi A, Valizadeh R, Naserian AA, et al. Effects of dietary supplementation of bentonite and Saccharomyces cerevisiae cell wall on acute-phase protein and liver function in high-producing dairy cows during transition period. Trop Anim Health Prod. 2019;51:1225. doi:10.1007/s11250-019-01815-3
- Zhang R, Xie X, Liu J, Pan R, Huang Y, et al. A novel selenoglycoside compound GlcSeCys alleviates diets-induced obesity and metabolic dysfunctions with the modulation of Galectin-1 and selenoproteins. Life Sci. 2024;359:123259. doi:10.1016/j.lfs.2024.123259
- Xiao S, Mao L, Xiao J, Wu Y, Liu H. Selenium nanoparticles inhibit the formation of atherosclerosis in apolipoprotein E deficient mice by alleviating hyperlipidemia and oxidative stress. Eur J Pharmacol. 2021;902:174120. doi:10.1016/j.ejphar.2021.174120
- Fang H, He X, Wu Y, Chen S, Zhang M, et al. Association Between Selenium Level in Blood and Glycolipid Metabolism in Residents of Enshi Prefecture, China. Biol Trace Elem Res. 2021;199:2456. doi:10.1007/s12011-020-02372-9
- Guo L, Xiao J, Liu H, Liu H. Selenium nanoparticles alleviate hyperlipidemia and vascular injury in ApoE-deficient mice by regulating cholesterol metabolism and reducing oxidative stress. Metallomics. 2020;12:204. doi:10.1039/c9mt00215d
- Carvalho RF, Huguenin GV, Luiz RR, Moreira AS, Oliveira GM, et al. Intake of partially defatted Brazil nut flour reduces serum cholesterol in hypercholesterolemic patients--a randomized controlled trial. Nutr J. 2015;14:59. doi:10.1186/s12937-015-0036-x
- Harisa GI, Abo-Salem OM, El-sayed el-SM, Shazly G. Effects of nutritional and excessive levels of selenium on red blood cells of rats fed a high cholesterol diet. Biol Trace Elem Res. 2013;152:41. doi:10.1007/s12011-012-9588-1
- Kaur H, Bansal MP. Studies on scavenger receptors under experimental hypercholesterolemia: modulation on selenium supplementation. Biol Trace Elem Res. 2011;143:310. doi:10.1007/s12011-010-8833-8
- Poirier J, Cockell KA, Ratnayake WM, Scoggan KA, Hidiroglou N, et al. Antioxidant Supplements Improve Profiles of Hepatic Oxysterols and Plasma Lipids in Butter-fed Hamsters. Nutr Metab Insights. 2010;3:1. doi:10.4137/NMI.S3911
- Kaur HD, Bansal MP. Studies on HDL associated enzymes under experimental hypercholesterolemia: possible modulation on selenium supplementation. Lipids Health Dis. 2009;8:55. doi:10.1186/1476-511X-8-55
- Agbor GA, Vinson JA, Patel S, Patel K, Scarpati J, et al. Effect of selenium- and glutathione-enriched yeast supplementation on a combined atherosclerosis and diabetes hamster model. J Agric Food Chem. 2007;55:8731.
- Dhingra S, Bansal MP. Hypercholesterolemia and LDL receptor mRNA expression: modulation by selenium supplementation. Biometals. 2006;19:493.
- Dhingra S, Bansal MP. Modulation of hypercholesterolemia-induced alterations in apolipoprotein B and HMG-CoA reductase expression by selenium supplementation. Chem Biol Interact. 2006;161:49.
- Dhingra S, Bansal MP. Hypercholesterolemia and apolipoprotein B expression: regulation by selenium status. Lipids Health Dis. 2005;4:28.
- Leborgne L, Pakala R, Dilcher C, Hellinga D, Seabron R, et al. Effect of antioxidants on atherosclerotic plaque formation in balloon-denuded and irradiated hypercholesterolemic rabbits. J Cardiovasc Pharmacol. 2005;46:540.
- Sato J, O'Brien T, Katusic ZS, Fu A, Nygren J, et al. Dietary antioxidants preserve endothelium dependent vasorelaxation in overfed rats. Atherosclerosis. 2002;161:327.
- Iizuka Y, Sakurai E, Tanaka Y. [Effect of selenium on serum, hepatic and lipoprotein lipids concentration in rats fed on a high-cholesterol diet]. Yakugaku Zasshi. 2001;121:93.
